A new efficient synthesis for 2-thiopteridine-4,6,7-triones (6-10, 15) has been found in the condendation of the appropriate 5,6-diaminopyrimidine (1-5, 14) with oxalic acid in DMF.Analogous condensations with dimethyl oxalate led to S-alkylation probably via an intermediate O-methylation of the DMF.8-Methyl-2- thiopteridine-4,6,7-trione (10) shows
Phthalate esters (PEs, Phthalates) are environmentally ubiquitous as a result of their extensive use as plasticizers and additives in diverse consumer products.Considerable concern relates to their reported xenoestrogenicity and consequently, microbial-based attenuation of environmental PE concentrations is of interest to combat harmful downstream
The article is aimed at considering the theoretic and methodical bases of organization of accountance in health and fitness institutions.It is proved that efficient managerial decision-making, which will simultaneously ensure positive economic results of activities of health and fitness institutions and the development of a healthy society in gener
Education has a momentous and influential role in developing this country.The specific function of educational management may not be fully depended on the central government.In line Griller Simmerstat with local autonomy era, local government (municipality) must also be able to initiate and play its extended role in order to enhance the educational